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Research Papers in Nutrition Science and Human Health

Del Rio (Dietary Bioactives), Ray (Nutrition and Vascular Studies) and

Grosso (Nutrition Research Syntheses and Epidemiology)

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Peer-Reviewed and Indexed Journal Papers

Ziauddeen, N; Rosi, A; Del Rio, D; Amoutzopoulos, B; Nicholson, S; Page, P; Scazzina, F; Brighenti, F; Ray, S; Mena, P. Dietary intake of (poly)phenols in children and adults: cross-sectional analysis of UK National Diet and Nutrition Survey Rolling Programme (2008–2014). Eur J Nutr (2018)

 

Grosso, Giuseppe. Dietary Antioxidants and Prevention of Non-Communicable Diseases (2018). Antioxidants7, no. 7: 94.

 

Godos J, Castellano S, Ray S, Grosso G, Galvano F. Dietary Polyphenol Intake and Depression: Results from the Mediterranean Healthy Eating, Lifestyle and Aging (MEAL) Study. Molecules. (2018) Apr 24;23(5). pii: E999. doi: 10.3390/molecules23050999. PubMed PMID: 29695122.

 

Grosso, G. Effects of Polyphenol-Rich Foods on Human Health. Nutrients 2018, 10, 1089.

 

Marranzano, M., Ray, S., Godos, J., Galvano, F. Association between dietary flavonoids intake and obesity in a cohort of adults living in the Mediterranean area. Int. J. Food Sci. Nutr. 2018

 

Savi M, Bocchi L, Bresciani L, Falco A, Quaini F, Mena P, Brighenti F, Crozier, A, Stilli D, Del Rio D. Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide. Molecules. 2018

 

Pereira-Caro G, Ordóñez JL, Ludwig I, Gaillet S, Mena P, Del Rio D, Rouanet, JM, Bindon KA, Moreno-Rojas JM, Crozier A. Development and validation of an UHPLC-HRMS protocol for the analysis of flavan-3-ol metabolites and catabolites in urine, plasma and feces of rats fed a red wine proanthocyanidin extract. Food Chem. 2018

 

Martini D, Innocenti A, Cosentino C, Bedogni G, Angelino D, Biasini B, Zavaroni I, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Passeri G, Pruneti C, Del Rio D. Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006. Nutrients. 2018

 

Martini D, Biasini B, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims proposed under European Community Regulation 1924/2006 in the area of blood glucose and insulin concentrations. Acta Diabetol. 2018

 

Biasini B, Marchi L, Angelino D, Bedogni G, Zavaroni I, Pruneti C, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Passeri G, Ventura M, Del Rio D,  Martini D. Claimed effects, outcome variables and methods of measurement for health claims on foods related to the gastrointestinal tract proposed under regulation (EC) 1924/2006. Int J Food Sci Nutr. 2018

 

Martini D, Angelino D, Cortelazzi C, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Di Nuzzo S, De Felici MB, Del Rio D. Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims Proposed Under European Community Regulation 1924/2006 in the Framework of Maintenance of Skin Function. Nutrients. 2017

 

Spigoni V, Mena P, Fantuzzi F, Tassotti M, Brighenti F, Bonadonna RC, Del Rio D, Dei Cas A. Bioavailability of Bergamot (Citrus bergamia) Flavanones and Biological Activity of Their Circulating Metabolites in Human Pro-Angiogenic Cells. Nutrients. 2017

 

Nunes S, Danesi F, Del Rio D, Silva P. Resveratrol and inflammatory bowel disease: the evidence so far. Nutr Res Rev. 2017

 

Grosso G, Bella F, Godos J, Sciacca S, Del Rio D, Ray S, Galvano F, Giovannucci EL. Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutr Rev. 2017

 

Shivappa N, Godos J, Hébert JR, Wirth MD, Piuri G, Speciani AF, Grosso G. Dietary Inflammatory Index and Colorectal Cancer Risk-A Meta-Analysis. Nutrients. 2017

 

Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Galvano F, Boffetta P. Health risk factors associated with meat, fruit and vegetable consumption in cohort studies: A comprehensive meta-analysis. PLoS One. 2017 

 

Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Bes-Rastrollo M, Galvano F, Martinez-Gonzalez MA. Long-Term Coffee Consumption Is Associated with Decreased Incidence of New-Onset Hypertension: A Dose-Response Meta-Analysis. Nutrients. 2017 

 

Ticinesi A, Lauretani F, Milani C, Nouvenne A, Tana C, Del Rio D, Maggio M, Ventura M, Meschi T. Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut-Muscle Axis? Nutrients. 2017

 

Escudero-López B, Ortega Á, Cerrillo I, Rodríguez-Griñolo MR, Muñoz-Hernández R, Macher HC, Martín F, Hornero-Méndez D, Mena P, Del Rio D, Fernández-Pachón MS. Consumption of orange fermented beverage improves antioxidant status and reduces peroxidation lipid and inflammatory markers in healthy humans. J Sci Food Agric. 2017 

 

Mena P, Tassotti M, Martini D, Rosi A, Brighenti F, Del Rio D. The Pocket-4-Life project, bioavailability and beneficial properties of the bioactive compounds of espresso coffee and cocoa-based confectionery containing coffee: study protocol for a randomized cross-over trial. Trials. 2017

 

Ferrario C, Statello R, Carnevali L, Mancabelli L, Milani C, Mangifesta M, Duranti S, Lugli GA, Jimenez B, Lodge S, Viappiani A, Alessandri G, Dall'Asta M, Del Rio D, Sgoifo A, van Sinderen D, Ventura M, Turroni F. How to Feed the Mammalian Gut Microbiota: Bacterial and Metabolic Modulation by Dietary Fibers. Front Microbiol. 2017

 

Martini D, Biasini B, Rossi S, Zavaroni I, Bedogni G, Musci M, Pruneti C, Passeri G, Ventura M, Galli D, Mirandola P, Vitale M, Dei Cas A, Bonadonna RC, Del Rio D. Claimed effects, outcome variables and methods of measurement for health claims on foods proposed under European Community Regulation 1924/2006 in the area of appetite ratings and weight management. Int J Food Sci Nutr. 2017

 

Del Rio D, Zimetti F, Caffarra P, Tassotti M, Bernini F, Brighenti F, Zini A, Zanotti I. The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid. Nutrients. 2017

 

Vauzour, D., Rodriguez-Ramiro, I., Rushbrook, S., Ipharraguerre, I.R., Bevan, D., Davies, S., Tejera, N., Mena, P., de Pascual-Teresa, S., Del Rio, D., Gavrilovic, J., Minihane, A.M. n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD (2018) Biochimica et Biophysica Acta - Molecular Basis of Disease

 

Mocciaro, G., Ziauddeen, N., Godos, J., Marranzano, M., Chan, M., Ray, S. Does a Mediterranean-type dietary pattern exert a cardio-protective effect outside the Mediterranean region? A review of current evidence (2017) International Journal of Food Sciences and Nutrition

 

Rosi, A., Mena, P., Pellegrini, N., Turroni, S., Neviani, E., Ferrocino, I., Di Cagno, R., Ruini, L., Ciati, R., Angelino, D., Maddock, J., Gobbetti, M., Brighenti, F., Del Rio, D., Scazzina, F. Environmental impact of omnivorous, ovo-lacto-vegetarian, and vegan diet (2017)

 

Aragonès, G., Danesi, F., Del Rio, D., Mena, P. The importance of studying cell metabolism when testing the bioactivity of phenolic compounds (2017) Trends in Food Science and Technology

 

Del Rio,D., Zimetti, F., Caffarra, P., Tassotti, M., Bernini, F., Brighenti, F., Zini, A., Zanotti, I. The gut microbial metabolite trimethylamine-N-oxide is present in human cerebrospinal fluid (2017) Nutrients

 

Ferrario, C., Statello, R., Carnevali, L., Mancabelli, L., Milani, C., Mangifesta, M., Duranti, S., Lugli, G.A., Jimenez, B., Lodge, S., Viappiani, A., Alessandri, G., Dall'Asta, M., Del Rio, D., Sgoifo, A., van Sinderen, D., Ventura, M., Turroni, F. How to feed the Mammalian gut microbiota: Bacterial and metabolic modulation by dietary fibers (2017) Frontiers in Microbiology

 

Godos, J., Micek, A., Marranzano, M., Salomone, F., Del Rio, D., Ray, S. Coffee consumption and risk of biliary tract cancers and liver cancer: A dose–response meta-analysis of prospective cohort studies (2017) Nutrients

 

Mele, L., Bidault, G., Mena, P., Crozier, A., Brighenti, F., Vidal-Puig, A., Del Rio, D. Dietary (poly)phenols, brown adipose tissue activation, and energy expenditure: A narrative review (2017) Advances in Nutrition

 

Brindani, N., Mena, P., Calani, L., Benzie, I., Choi, S.-W., Brighenti, F., Zanardi, F., Curti, C., Del Rio, D. Synthetic and analytical strategies for the quantification of phenyl-γ-valerolactone conjugated metabolites in human urine (2017) Molecular Nutrition and Food Research

 

Mele, L., Carobbio, S., Brindani, N., Curti, C., Rodriguez-Cuenca, S., Bidault, G., Mena, P., Zanotti, I., Vacca, M., Vidal-Puig, A., Del Rio, D.

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function (2017) Molecular Nutrition and Food Research

 

Savi, M., Bocchi, L., Mena, P., Dall'Asta, M., Crozier, A., Brighenti, F., Stilli, D., Del Rio, D. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats (2017) Cardiovascular Diabetology

 

Pereira-Caro, G., Moreno-Rojas, J.M., Brindani, N., Del Rio, D., Lean, M.E.J., Hara, Y., Crozier, A. Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism (2017) Journal of Agricultural and Food Chemistry

 

Angelino, D., Cossu, M., Marti, A., Zanoletti, M., Chiavaroli, L., Brighenti, F., Del Rio, D., Martini, D. Bioaccessibility and bioavailability of phenolic compounds in bread: A review (2017) Food and Function

 

Juániz, I., Ludwig, I.A., Bresciani, L., Dall'Asta, M., Mena, P., Del Rio, D., Cid, C., de Peña, M.-P. Corrigendum to “Bioaccessibility of (poly)phenolic compounds of raw and cooked cardoon (Cynara cardunculus L.) after simulated gastrointestinal digestion and fermentation by human colonic microbiota” (2017) Journal of Functional Foods

 

Juániz, I., Ludwig, I.A., Bresciani, L., Dall'Asta, M., Mena, P., Del Rio, D., Cid, C., de Peña, M.-P. Bioaccessibility of (poly)phenolic compounds of raw and cooked cardoon (Cynara cardunculus L.) after simulated gastrointestinal digestion and fermentation by human colonic microbiota (2017) Journal of Functional Foods

 

Bresciani, L., Martini, D., Mena, P., Tassotti, M., Calani, L., Brigati, G., Brighenti, F., Holasek, S., Malliga, D.-E., Lamprecht, M., Del Rio, D.

Absorption profile of (Poly)phenolic compounds after consumption of three food supplements containing 36 different fruits, vegetables, and berries (2017) Nutrients

 

Mena, P., Dall’Asta, M., Calani, L., Brighenti, F., Del Rio, D. Gastrointestinal stability of urolithins: an in vitro approach (2017) European Journal of Nutrition

 

Mena, P., González de Llano, D., Brindani, N., Esteban-Fernández, A., Curti, C., Moreno-Arribas, M.V., Del Rio, D., Bartolomé, B.

5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells (2017) Journal of Functional Foods

 

Ounnas, F., De Lorgeril, M., Salen, P., Laporte, F., Calani, L., Mena, P., Brighenti, F., Del Rio, D., Demeilliers, C. Rye polyphenols and the metabolism of n-3 fatty acids in rats: A dose dependent fatty fish-like effect (2017) Scientific Reports

 

Grosso G, Godos J, Galvano F, Giovannucci EL (2017). Coffee, caffeine and health outcomes: an umbrella review. Annual Review of Nutrition.

 

Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Galvano F, Giovannucci EL. Dietary Flavonoid and Lignan Intake and Mortality in Prospective Cohort Studies:  Systematic Review and Dose-Response Meta-Analysis (2017). American Journal of Epidemiology.

 

Grosso G, Godos J, Lamuela-Raventos R, Ray S, Micek A, Pajak A, Sciacca S, D'Orazio N, Del Rio D, Galvano F (2017). A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Molecular Nutrition and Food Research.

 

Juániz, I., Ludwig, I.A., Bresciani, L., Dall'Asta, M., Mena, P., Del Rio, D., Cid, C., de Peña, M.-P. Catabolism of raw and cooked green pepper (Capsicum annuum) (poly)phenolic compounds after simulated gastrointestinal digestion and faecal fermentation (2016) Journal of Functional Foods

 

Mele, L., Mena, P., Piemontese, A., Marino, V., López-Gutiérrez, N., Bernini, F., Brighenti, F., Zanotti, I., Del Rio, D. Antiatherogenic effects of ellagic acid and urolithins in vitro (2016) Archives of Biochemistry and Biophysics

 

Sayegh, Marietta; Del Rio, Daniele; Ray, S; NSA Nutritional supplementation Trial of fruit and vegetable extracts and Vascular function (NNTV): Improvement to microvascular function using Laser Doppler Iontophoresis, following consumption of encapsulated fruit and veg powder over 12 weeks (compared with placebo), in overweight and obese human adults (2016). The Federation of American Societies for Experimental Biology.

 

Sayegh, M., Tsiountsioura, M., Page, P., Del Rio, D., Ray, S. National Safety Associates nutritional supplementation trial of fruit and vegetable extracts and vascular function (NNTV): Study protocol for a randomised controlled trial (2016) Trials

 

Tsiountsioura M, Sayegh M, Ray S (2016). Can consumption of a vitamin C rich fruit and vegetable derived supplement for 12 weeks, reduce blood pressure in normotensive overweight/obese individuals? The Federation of American Societies for Experimental Biology.

 

Dall’Asta, M., Bresciani, L., Calani, L., Cossu, M., Martini, D., Melegari, C., Del Rio, D., Pellegrini, N., Brighenti, F., Scazzina, F. In vitro bioaccessibility of phenolic acids from a commercial aleurone-enriched bread compared to a whole grain bread (2016) Nutrients

 

Bresciani, L., Scazzina, F., Leonardi, R., Dall'Aglio, E., Newell, M., Dall'Asta, M., Melegari, C., Ray, S., Brighenti, F., Del Rio, D. Bioavailability and metabolism of phenolic compounds from wholegrain wheat and aleurone-rich wheat bread (2016) Molecular Nutrition and Food Research

 

Sayegh M, Tsiountsioura M, Ray S (2016). Can a fruit and vegetable derived supplement, rich in vitamin-C, modulate cIMT and FMD measurements in overweight and obese individuals over 12 weeks? The FASEB Journal.

 

Bhat S., Maddock J., & Ray S. The relationship between Dietary Patterns and Carotid Intima Media Thickness, as an early biomarker of Cardiovascular Disease. (April 2016). The FASEB Journal.

 

Dall’Asta, M., Bayle, M., Neasta, J., Scazzina, F., Bruni, R., Cros, G., Del Rio, D., Oiry, C. Protection of pancreatic β-cell function by dietary polyphenols (2015) Phytochemistry Reviews

 

Ludwig, I.A., Mena, P., Calani, L., Borges, G., Pereira-Caro, G., Bresciani, L., Del Rio, D., Lean, M.E.J., Crozier, A. New insights into the bioavailability of red raspberry anthocyanins and ellagitannins (2015) Free Radical Biology and Medicine

 

Mena, P., Dall’Asta, M., Calani, L., Brighenti, F., Del Rio, D. Gastrointestinal stability of urolithins: an in vitro approach (2015) European Journal of Nutrition

 

Bresciani, L., Calani, L., Cossu, M., Mena, P., Sayegh, M., Ray, S., Del Rio, D. (Poly)phenolic characterization of three food supplements containing 36 different fruits, vegetables and berries (2015) PharmaNutrition

 

Zanotti, I., Dall'Asta, M., Mena, P., Mele, L., Bruni, R., Ray, S., Del Rio, D. Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism (2015) Food and Function

 

Curti, C., Brindani, N., Battistini, L., Sartori, A., Pelosi, G., Mena, P., Brighenti, F., Zanardi, F. & Del Rio, D. (2015) Catalytic, Enantioselective Vinylogous Mukaiyama Aldol Reaction Of Furan-Based Dienoxy Silanes: A Chemodivergent Approach To Γ-Valerolactone Flavan-3-Ol Metabolites And Δ-Lactone Analogues. Advanced Synthesis & Catalysis.

 

Ray S et al (2015). Can antioxidant-rich blackcurrant juice drink consumption improve photoprotection against ultraviolet radiation?British Journal of Dermatology

 

Maddock J, Abmrosini G, Koulman A, Ray S. (2015) A Proposed Epidemiological Approach to Investigate Mechanisms between Diet and Vascular Function. The FASEB Journal, 2015. 

 

Tsiountsioura M, Sayegh M, Ray S. (2015) Does Habitual Fruit Consumption Modulate Microvascular Endothelial Function in Healthy Human Participants? The FASEB Journal, 2015. 

 

Sayegh M, Ray S. (2015) Potential Modulation of Vascular Function Relating to Baseline Hydration Status in Healthy Human Participants in a Randomised Controlled Trial. The FASEB Journal, 2015. 

 

Ray S, Nicholson S, Ziauddeen N, Steer T, Cole D, Solis-Trapala I, Amoutzopoulos B, Page P. (2015) What do we know about fruit and vegetable consumption in the UK? Trends from the National Diet and Nutrition Survey Rolling Programme (NDNS RP). The FASEB Journal, 2015. 

 

Tomatis V, Ray S, Siervo M, Griffin J, Bluck L. (2015) Effects of Green Tea and Coffee Polyphenols on Cardiometabolic Function in Women with Polycystic Ovary Syndrome. The FASEB Journal, 2015. 

 

Jones N, Ray S, Monsivais P. (2015) The DASH Diet, Cardiovascular Disease Risk and Obesity in the United Kingdom. The FASEB Journal, 2015. 

 

Ray S, Nicholson S, Roberts C, Page P. (2014) UK National Diet and Nutrition (NDNS) Survey: ad-hoc cross-sectional survey to sustainable Rolling Programme (RP) for surveillance (Y6-9 2013-17). The FASEB Journal, 2014. 

 

Sayegh M, Ray S. (2014) Acute hydration status and micro-vascular function in healthy human volunteers. The FASEB Journal, 2014.

 

Zanotti I, Dallasta M, Menaparreno P, Mele L, Bruni R, Ray S, Del Rio D. (2014) Atheroprotective effects of (poly)phenols: focus on cell cholesterol metabolism. Food and Function, 2014.

 

Khan F, Ray S, Craigie A.M, Kennedy G, Hill A, Barton K.L, Broughton J. & Belch, J.J. (2014) Lowering of oxidative stress improves endothelial function in healthy subjects with habitually low intakes of fruit and vegetables: A randomized controlled trial of antioxidant- and polyphenol-rich blackcurrant juice. Free Radic Biol Med, 2014. 

 

Ray S, Miglio C, Eden T, & Del Rio D. (2014) Assessment of vascular and endothelial dysfunction in nutritional studies. Nutrition, Metabolism and Cardiovascular Diseases. doi: 10.1016/j.numecd.2014.03.011  

 

Sayegh M, Miglio C, & Ray S. (2014) Potential cardiovascular implications of Sea Buckthorn berry consumption in humans. International Journal of Food Sciences and Nutrition. doi:10.3109/09637486.2014.880672 

 

Dall’Asta M, Derlindati E, Curella V, Mena P, Calani, L, Ray S, Zavaroni I, Brighenti F, Del Rio D (2013). Effects of naringenin and its phase II metabolites on in vitro human macrophage gene expression. International Journal of Food Sciences and Nutrition. vol 64 no 7, 843–9. doi:10.3109/09637486.2013.804039 

 

Bresciani L, Calani L, Bocchi L, Delucchi F, Savi M, Ray S, Brighenti F, Stilli D, Del Rio D. (2013) Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats. (2013) Nutr Metab CardiovascDis. doi:10.1016/j.numecd.2013.09.008.

 

Eden T, Sayegh M, Ray S. (2012) Diagnosis and management of Raynaud’s phenomenon. BMJ (Rapid Response Published 14 February 2012)

 

The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischemia. (2011) Belch JJ, Ray S, Rajput-Ray M, Engeset J, Fagrell B, Lepäntalo M, McKay A, Mackay IR, Ostergren J, Ruckley CV, Salenius J. Int Angiol. 2011 Apr;30(2):150-5. PMID: 21427652.

 

Nutritional management of Stroke: From Current Evidence to Conjecture. (2007) Ray S, Rana P, Rajput M, Haleem MA. Nutrition Bulletin, vol. 32, no. 2, pp. 145–153, 2007

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