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Primary Research Outputs

Del Rio (Dietary Bioactives), Ray (Nutrition and Vascular Studies) and

Grosso (Nutrition Research Syntheses and Epidemiology)

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Journal Papers

Vauzour, D., Rodriguez-Ramiro, I., Rushbrook, S., Ipharraguerre, I.R., Bevan, D., Davies, S., Tejera, N., Mena, P., de Pascual-Teresa, S., Del Rio, D., Gavrilovic, J., Minihane, A.M. n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD (2018) Biochimica et Biophysica Acta - Molecular Basis of Disease


Mocciaro, G., Ziauddeen, N., Godos, J., Marranzano, M., Chan, M., Ray, S. Does a Mediterranean-type dietary pattern exert a cardio-protective effect outside the Mediterranean region? A review of current evidence (2017) International Journal of Food Sciences and Nutrition


Rosi, A., Mena, P., Pellegrini, N., Turroni, S., Neviani, E., Ferrocino, I., Di Cagno, R., Ruini, L., Ciati, R., Angelino, D., Maddock, J., Gobbetti, M., Brighenti, F., Del Rio, D., Scazzina, F. Environmental impact of omnivorous, ovo-lacto-vegetarian, and vegan diet (2017)


Aragonès, G., Danesi, F., Del Rio, D., Mena, P. The importance of studying cell metabolism when testing the bioactivity of phenolic compounds (2017) Trends in Food Science and Technology


Del Rio,D., Zimetti, F., Caffarra, P., Tassotti, M., Bernini, F., Brighenti, F., Zini, A., Zanotti, I. The gut microbial metabolite trimethylamine-N-oxide is present in human cerebrospinal fluid (2017) Nutrients


Ferrario, C., Statello, R., Carnevali, L., Mancabelli, L., Milani, C., Mangifesta, M., Duranti, S., Lugli, G.A., Jimenez, B., Lodge, S., Viappiani, A., Alessandri, G., Dall'Asta, M., Del Rio, D., Sgoifo, A., van Sinderen, D., Ventura, M., Turroni, F. How to feed the Mammalian gut microbiota: Bacterial and metabolic modulation by dietary fibers (2017) Frontiers in Microbiology


Godos, J., Micek, A., Marranzano, M., Salomone, F., Del Rio, D., Ray, S. Coffee consumption and risk of biliary tract cancers and liver cancer: A dose–response meta-analysis of prospective cohort studies (2017) Nutrients


Mele, L., Bidault, G., Mena, P., Crozier, A., Brighenti, F., Vidal-Puig, A., Del Rio, D. Dietary (poly)phenols, brown adipose tissue activation, and energy expenditure: A narrative review (2017) Advances in Nutrition


Brindani, N., Mena, P., Calani, L., Benzie, I., Choi, S.-W., Brighenti, F., Zanardi, F., Curti, C., Del Rio, D. Synthetic and analytical strategies for the quantification of phenyl-γ-valerolactone conjugated metabolites in human urine (2017) Molecular Nutrition and Food Research


Mele, L., Carobbio, S., Brindani, N., Curti, C., Rodriguez-Cuenca, S., Bidault, G., Mena, P., Zanotti, I., Vacca, M., Vidal-Puig, A., Del Rio, D.

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function (2017) Molecular Nutrition and Food Research


Savi, M., Bocchi, L., Mena, P., Dall'Asta, M., Crozier, A., Brighenti, F., Stilli, D., Del Rio, D. In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats (2017) Cardiovascular Diabetology


Pereira-Caro, G., Moreno-Rojas, J.M., Brindani, N., Del Rio, D., Lean, M.E.J., Hara, Y., Crozier, A. Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism (2017) Journal of Agricultural and Food Chemistry


Angelino, D., Cossu, M., Marti, A., Zanoletti, M., Chiavaroli, L., Brighenti, F., Del Rio, D., Martini, D. Bioaccessibility and bioavailability of phenolic compounds in bread: A review (2017) Food and Function


Juániz, I., Ludwig, I.A., Bresciani, L., Dall'Asta, M., Mena, P., Del Rio, D., Cid, C., de Peña, M.-P. Corrigendum to “Bioaccessibility of (poly)phenolic compounds of raw and cooked cardoon (Cynara cardunculus L.) after simulated gastrointestinal digestion and fermentation by human colonic microbiota” (2017) Journal of Functional Foods


Juániz, I., Ludwig, I.A., Bresciani, L., Dall'Asta, M., Mena, P., Del Rio, D., Cid, C., de Peña, M.-P. Bioaccessibility of (poly)phenolic compounds of raw and cooked cardoon (Cynara cardunculus L.) after simulated gastrointestinal digestion and fermentation by human colonic microbiota (2017) Journal of Functional Foods


Bresciani, L., Martini, D., Mena, P., Tassotti, M., Calani, L., Brigati, G., Brighenti, F., Holasek, S., Malliga, D.-E., Lamprecht, M., Del Rio, D.

Absorption profile of (Poly)phenolic compounds after consumption of three food supplements containing 36 different fruits, vegetables, and berries (2017) Nutrients


Mena, P., Dall’Asta, M., Calani, L., Brighenti, F., Del Rio, D. Gastrointestinal stability of urolithins: an in vitro approach (2017) European Journal of Nutrition


Mena, P., González de Llano, D., Brindani, N., Esteban-Fernández, A., Curti, C., Moreno-Arribas, M.V., Del Rio, D., Bartolomé, B.

5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells (2017) Journal of Functional Foods


Ounnas, F., De Lorgeril, M., Salen, P., Laporte, F., Calani, L., Mena, P., Brighenti, F., Del Rio, D., Demeilliers, C. Rye polyphenols and the metabolism of n-3 fatty acids in rats: A dose dependent fatty fish-like effect (2017) Scientific Reports


Grosso G, Godos J, Galvano F, Giovannucci EL (2017). Coffee, caffeine and health outcomes: an umbrella review. Annual Review of Nutrition.


Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Galvano F, Giovannucci EL. Dietary Flavonoid and Lignan Intake and Mortality in Prospective Cohort Studies:  Systematic Review and Dose-Response Meta-Analysis (2017). American Journal of Epidemiology.


Grosso G, Godos J, Lamuela-Raventos R, Ray S, Micek A, Pajak A, Sciacca S, D'Orazio N, Del Rio D, Galvano F (2017). A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations. Molecular Nutrition and Food Research.


Juániz, I., Ludwig, I.A., Bresciani, L., Dall'Asta, M., Mena, P., Del Rio, D., Cid, C., de Peña, M.-P. Catabolism of raw and cooked green pepper (Capsicum annuum) (poly)phenolic compounds after simulated gastrointestinal digestion and faecal fermentation (2016) Journal of Functional Foods


Mele, L., Mena, P., Piemontese, A., Marino, V., López-Gutiérrez, N., Bernini, F., Brighenti, F., Zanotti, I., Del Rio, D. Antiatherogenic effects of ellagic acid and urolithins in vitro (2016) Archives of Biochemistry and Biophysics


Sayegh, M., Tsiountsioura, M., Page, P., Del Rio, D., Ray, S. National Safety Associates nutritional supplementation trial of fruit and vegetable extracts and vascular function (NNTV): Study protocol for a randomised controlled trial (2016) Trials


Dall’Asta, M., Bresciani, L., Calani, L., Cossu, M., Martini, D., Melegari, C., Del Rio, D., Pellegrini, N., Brighenti, F., Scazzina, F. In vitro bioaccessibility of phenolic acids from a commercial aleurone-enriched bread compared to a whole grain bread (2016) Nutrients


Bresciani, L., Scazzina, F., Leonardi, R., Dall'Aglio, E., Newell, M., Dall'Asta, M., Melegari, C., Ray, S., Brighenti, F., Del Rio, D. Bioavailability and metabolism of phenolic compounds from wholegrain wheat and aleurone-rich wheat bread (2016) Molecular Nutrition and Food Research


Dall’Asta, M., Bayle, M., Neasta, J., Scazzina, F., Bruni, R., Cros, G., Del Rio, D., Oiry, C. Protection of pancreatic β-cell function by dietary polyphenols (2015) Phytochemistry Reviews


Ludwig, I.A., Mena, P., Calani, L., Borges, G., Pereira-Caro, G., Bresciani, L., Del Rio, D., Lean, M.E.J., Crozier, A. New insights into the bioavailability of red raspberry anthocyanins and ellagitannins (2015) Free Radical Biology and Medicine


Mena, P., Dall’Asta, M., Calani, L., Brighenti, F., Del Rio, D. Gastrointestinal stability of urolithins: an in vitro approach (2015) European Journal of Nutrition


Bresciani, L., Calani, L., Cossu, M., Mena, P., Sayegh, M., Ray, S., Del Rio, D. (Poly)phenolic characterization of three food supplements containing 36 different fruits, vegetables and berries (2015) PharmaNutrition


Zanotti, I., Dall'Asta, M., Mena, P., Mele, L., Bruni, R., Ray, S., Del Rio, D. Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism (2015) Food and Function


Curti, C., Brindani, N., Battistini, L., Sartori, A., Pelosi, G., Mena, P., Brighenti, F., Zanardi, F. & Del Rio, D. (2015) Catalytic, Enantioselective Vinylogous Mukaiyama Aldol Reaction Of Furan-Based Dienoxy Silanes: A Chemodivergent Approach To Γ-Valerolactone Flavan-3-Ol Metabolites And Δ-Lactone Analogues. Advanced Synthesis & Catalysis.


Ray S et al (2015). Can antioxidant-rich blackcurrant juice drink consumption improve photoprotection against ultraviolet radiation?British Journal of Dermatology


Maddock J, Abmrosini G, Koulman A, Ray S. (2015) A Proposed Epidemiological Approach to Investigate Mechanisms between Diet and Vascular Function. The FASEB Journal, 2015. 


Tsiountsioura M, Sayegh M, Ray S. (2015) Does Habitual Fruit Consumption Modulate Microvascular Endothelial Function in Healthy Human Participants? The FASEB Journal, 2015. 


Sayegh M, Ray S. (2015) Potential Modulation of Vascular Function Relating to Baseline Hydration Status in Healthy Human Participants in a Randomised Controlled Trial. The FASEB Journal, 2015. 


Ray S, Nicholson S, Ziauddeen N, Steer T, Cole D, Solis-Trapala I, Amoutzopoulos B, Page P. (2015) What do we know about fruit and vegetable consumption in the UK? Trends from the National Diet and Nutrition Survey Rolling Programme (NDNS RP). The FASEB Journal, 2015. 


Tomatis V, Ray S, Siervo M, Griffin J, Bluck L. (2015) Effects of Green Tea and Coffee Polyphenols on Cardiometabolic Function in Women with Polycystic Ovary Syndrome. The FASEB Journal, 2015. 


Jones N, Ray S, Monsivais P. (2015) The DASH Diet, Cardiovascular Disease Risk and Obesity in the United Kingdom. The FASEB Journal, 2015. 


Ray S, Nicholson S, Roberts C, Page P. (2014) UK National Diet and Nutrition (NDNS) Survey: ad-hoc cross-sectional survey to sustainable Rolling Programme (RP) for surveillance (Y6-9 2013-17). The FASEB Journal, 2014. 


Sayegh M, Ray S. (2014) Acute hydration status and micro-vascular function in healthy human volunteers. The FASEB Journal, 2014.


Zanotti I, Dallasta M, Menaparreno P, Mele L, Bruni R, Ray S, Del Rio D. (2014) Atheroprotective effects of (poly)phenols: focus on cell cholesterol metabolism. Food and Function, 2014.


Khan F, Ray S, Craigie A.M, Kennedy G, Hill A, Barton K.L, Broughton J. & Belch, J.J. (2014) Lowering of oxidative stress improves endothelial function in healthy subjects with habitually low intakes of fruit and vegetables: A randomized controlled trial of antioxidant- and polyphenol-rich blackcurrant juice. Free Radic Biol Med, 2014. 


Ray S, Miglio C, Eden T, & Del Rio D. (2014) Assessment of vascular and endothelial dysfunction in nutritional studies. Nutrition, Metabolism and Cardiovascular Diseases. doi: 10.1016/j.numecd.2014.03.011 


Sayegh M, Miglio C, & Ray S. (2014) Potential cardiovascular implications of Sea Buckthorn berry consumption in humans. International Journal of Food Sciences and Nutrition. doi:10.3109/09637486.2014.880672 


Dall’Asta M, Derlindati E, Curella V, Mena P, Calani, L, Ray S, Zavaroni I, Brighenti F, Del Rio D (2013). Effects of naringenin and its phase II metabolites on in vitro human macrophage gene expression. International Journal of Food Sciences and Nutrition. vol 64 no 7, 843–9. doi:10.3109/09637486.2013.804039 


Bresciani L, Calani L, Bocchi L, Delucchi F, Savi M, Ray S, Brighenti F, Stilli D, Del Rio D. (2013) Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats. (2013) Nutr Metab CardiovascDis. doi:10.1016/j.numecd.2013.09.008.


Eden T, Sayegh M, Ray S. (2012) Diagnosis and management of Raynaud’s phenomenon. BMJ (Rapid Response Published 14 February 2012)


The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischemia. (2011) Belch JJ, Ray S, Rajput-Ray M, Engeset J, Fagrell B, Lepäntalo M, McKay A, Mackay IR, Ostergren J, Ruckley CV, Salenius J. Int Angiol. 2011 Apr;30(2):150-5. PMID: 21427652.


Nutritional management of Stroke: From Current Evidence to Conjecture. (2007) Ray S, Rana P, Rajput M, Haleem MA. Nutrition Bulletin, vol. 32, no. 2, pp. 145–153, 2007.